Crab predation, waterborne cues, and inducible defenses in the blue mussel, Mytilus edulis. Saliva is the protective fluid for all tissues of the oral cavity. It protects the soft tissues from abrasion by rough materials and from chemicals.
Also due to the herbal nature and high biocompatibility of the mucilage, it is suggested that it could be considered as alternative candidate for synthetic polymers in the formulation of buccal mucoadhesive tablets.
Statistical optimization of Mucoadhesive Buccal Bilayered Tablets. The results of a study showed that muco-adhesion strength was significantly increased by increasing the contact time.
The basics and underlying mechanisms of mucoadhesion.
Adhesion of a matter to this layer is hence called mucoadhesion. Many biopolymers — proteins, carbohydratesglycoproteinsand mucopolysaccharides — may be used to form hydrogels that contribute to temporary adhesion. The subsequent formation of van der Waals, hydrogen and, in the case of a positively charged polymer, electrostatic bonds between the mucins and the hydrated polymer promotes prolonged adhesion.
Also known as electrostatic theory, this process involves the transfer of electrons across the interface between the substrate and adhesive. Adhesives with large surface groups will also experience a decrease in entropy as they approach the surface, creating repulsion.
Our results indicated that incorporation of HPMC in chlorhexidine tablets decreased the releasing rate of drug, probably because of absorption of water by the polymer and forming a gelatinous barrier layer at the surface of the tablet matrix, while the mucilage of Cordia myxa did not form a gel layer and therefore did not show any significant decrease in drug release.
Fracture theory looks for force required to separate at the interface, but fractures can occur due to cohesive failure within either of the layers. Please help improve this article by adding citations to reliable sources. The adhesive components in a liquid solution anchor themselves in irregularities on the substrate and eventually harden, providing sites on which to adhere.
Buccal mucoadhesive films can improve the drug therapeutic effect by enhancement of drug absorption Keywords: Fracture theory is the major mechanism by which to determine the mechanical strength of a particular mucoadhesive, and describes the force necessary to separate the two materials after mucoadhesion has occurred.
June Learn how and when to remove this template message Many permanent bioadhesives e. In the buccal region, a tablet may.International Journal of Pharma and Bio Sciences V1(2) FORMULATION AND EVALUATION OF MUCOADHESIVE TABLETS OF NIACIN USING DIFFERENT BIOADHESIVE POLYMERS.
Mucoadhesive tablets, in general, have the potential to be used for controlled release drug delivery, but coupling of mucoadhesive properties to tablet has additional advantages, e.g.
efficient absorption and enhanced. Mucoadhesive tablets of Cephalexin monohydrate were prepared with an objective to increase the bioavailability by minimizing the first pass metabolism and also to reduce the frequency of administration.
The aim of study was to prepare and characterize buccoadhesive tablets of Metoprolol tartrate using different Mucoadhesive polymers such as CarbopolSodium alginate and HPMC K4M in combination. Buccal Tablets of Lisinopril by Direct - Scientific Journals Buccal tablets of lisinopril were prepared by direct compression method using different hydrophilic Mucoadhesive buccal tablets containing Lisinopril were.
exploring the buccal delivery potential of an antiretroviral drug 2 Nov This thesis is submitted in partial fulfillment of. Thesis On Mucoadhesive Buccal Tablet - Noor. Research Interest: Design and Evaluation of Nanoparticles, Dendrimers, Resealed erythrocytes, Conjugated novel carriers, Liposomes, Nanosponges, Nanoparticles loaded creams, New binding agents for tablets, Novel Transdermal Drug Delivery Systems, Targeted Drug Delivery Systems.Download